Aparna was born into a Malayali family settled in Chennai. She was a theater artist and contemporary dancer before her acting debut. She has associated herself with ‘Koothu-P-Pattarai’, an avant-garde theatre movement of Chennai, and had also acted in renowned plays like ‘Six Characters in Search of an Author’, ‘Woyzeck’, ‘Moonshine’, ‘Sky Toffee’, ‘Sangadi Arinjo’ based on seven short stories of Vaikom Muhammad Basheer and several Shakespearean plays.
She debuted in movies with Martin Prakkat's ABCD: American-Born Confused Desi which became a super hit. She played the role of Madhumitha, a college student and the love interest of Dulquer Salmaan in the movie. Her second movie as heroine was Asif Ali starrer Bicycle Thieves.
She also acted female lead in Mamas' Mannar Mathai Speaking 2 which is a sequel to 1995 cult comedy Mannar Mathai Speaking and Boban Samuel's Happy Journey starred Jayasurya. She also acts as a Junior journalist in director Venu's film Munnariyippu starring Mammootty which received rave reviews for her acting skills. She had signed Mohanlal-Priyadarshan Film Ammu to Ammu but was later shelved due to production difficulties. In 2016, she completed Kranthi which saw no theatrical release.